[HTML][HTML] CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p–XIAP axis
J Shang, WM Chen, ZH Wang, TN Wei, ZZ Chen… - Experimental …, 2019 - Elsevier
The contribution and role of circular RNAs (circRNAs) in mediating chemoresistance in
acute myeloid leukemia (AML) are still poorly understood and need further investigation. In
this study, we established a doxorubicin (ADM)-resistant THP-1 AML cell line (THP-1/ADM).
A high-throughput microarray was used to identify circRNA expression profiles of THP-
1/ADM cells and naive THP-1 cells. The identified potential functional circRNA molecule was
further validated in THP-1/ADM cells and bone marrow (BM) specimens from 42 AML …
acute myeloid leukemia (AML) are still poorly understood and need further investigation. In
this study, we established a doxorubicin (ADM)-resistant THP-1 AML cell line (THP-1/ADM).
A high-throughput microarray was used to identify circRNA expression profiles of THP-
1/ADM cells and naive THP-1 cells. The identified potential functional circRNA molecule was
further validated in THP-1/ADM cells and bone marrow (BM) specimens from 42 AML …